Final Program
PASPCR 2012 (Deer Valley, Utah) September 19-22
The Power of Genetics and Pigmentation
|
Wednesday, Sept 19, 2012 |
|
| 1:00 – 5:00 pm |
Melanoma patient support meeting |
| 1:00 – 5:00 pm |
Vitiligo patient support meeting |
| 5:00 – 6:00 pm |
Optical Magic: adaptive coloration, patterning, and 3D texture in octopus skin |
| 6:00 – 9:00 pm | Welcome reception |
|
Thursday, Sept 20, 2012: Genetics and Development |
|
| 8:00 – 9:00 am | Breakfast |
| 9:00 – 9:15 am |
Welcome and opening remarks |
| 9:15 – 11:15 pm |
Plenary session I: Natural selection for pigmentary traits |
| 9:15 – 9:40 am | Pelage and predators Hopi Hoekstra (Harvard University, Boston, MA) |
| 9:40 – 10:05 am |
Variation of human eye, hair, and skin color |
| 10:05 – 10:30 am |
Color patterns in Heliconius butterflies: genetics and selection |
| 10:30 – 10:55 am |
Adaptive variation in pigeons |
| 10:55 – 11:15 am | Panel Discussion (Andersson, Manga) |
| 11:15 – 11:30 am | Break |
| 11:30 – 12:30 pm |
Aaron B Lerner award and lecture |
| 12:30 – 1:45 pm | Lunch and poster viewing |
| 1:45 – 3:25 am |
Oral session I: Developmental biology and Genetics |
| 1:45 pm |
"Paf1 complex regulates transcription pausing required to maintain pluripotent neural crest progenitors" |
| 2:00 pm |
"Melanocyte stem cell niche and pigment patterning in regenerating feathers" |
| 2:15 pm |
"Differential regulation of SOX10 during the maintenance of the melanocyte lineage and establishment of the melanocyte stem cell" |
| 2:30 pm |
"Direct regulation of melanocyte differentiation by the AP2 transcription factor family" |
| 2:45 pm |
"Shp2, a non-receptor tyrosine phosphatase mutated in LEOPARD syndrome, is regulated by the neural guidance receptor plexin B1 in human melanocytes" |
| 3:00 pm |
"Genetic studies of vitiligo provide new insights into an ancient disease" |
| 3:25 – 5:00 pm |
Poster session I: Basic science |
| Optional evening activities | |
|
Friday, Sept 21, 2012: Model systems for studying pigmentary biology and disease |
|
| 8:00 – 9:00 am | Breakfast |
| 9:00 – 11:00 am |
Plenary session II: Animal models of pigmentary biology and disease |
| 9:00 – 9:25 am |
Modeling melanoma in mice |
| 9:25 – 9:50 am |
Pharmacologic modulation of melanogenesis |
| 9:50 – 10:15 am |
Animal models of vitiligo |
| 10:15 – 10:40 am |
Pigmentary variation and disease in domestic animals |
| 10:40 – 11:00 am | Break |
| 11:00 – 11:25 am |
Melanocyte development in zebrafish |
| 11:25 – 11:50am |
Zebrafish models of melanocytic disorders |
| 11:50 – 12:15 am | Systems Genetics of Molecular Networks: The Glaucoma-Pigmentation Link Rob Williams (University of Tennessee, Memphis, TN) |
| 12:15 – 12:30 pm |
Panel Discussion (Merlino, Lang, Valencia) |
| 12:30 – 1:45 pm | Lunch and poster viewing/PASPCR Council Meeting |
| 1:45 – 3:25 pm |
Oral session II: Environmental modulation of pigmentary phenotypes |
| 1:45 pm |
"p53 and paracrine regulation of pigmentation and melanoma" |
| 2:00 pm |
"ET-1 is a transcriptional target of p53 in epidermal keratinocytes and controls UV radiation-induced melanocyte homeostasis in vivo" |
| 2:15 pm |
"Transfer of catalase from melanocytes to keratinocytes: a new mechanism that protects the skin from oxidative stress" |
| 2:30 pm |
"1, 25 (OH)2 vitamin D3 is a paracrine factor that participates in the DNA damage response of human melanocytes to UV" |
| 2:45 pm |
"Role of SWI/SNF enzymes in the repair of UV-induced DNA damage" |
| 3:00 pm |
"A multifaceted role for melanosomes in the stress susceptibility of ARPE-19 cells" |
| 3:25 – 5:00 pm | Poster session II: Translational/clinical science Chairs: Frank Meyskens (University of California, Irvine, CA) and Doug Grossman (University of Utah, Salt lake City, UT) |
| 6:30 pm | Gala dinner |
|
Saturday, Sept 22, 2012: Advances in melanoma genetics and therapy |
|
|
7:30 – 8:00 am |
Breakfast |
|
8:00 - 8:30 am |
PASPCR Business meeting of all members Chaired by Greg Barsh, PhD, President |
| 8:35 – 10:40am | Plenary session III: Genetics and genomics of melanoma Chairs: Claus Garbe (Univ. of Tuebingen, Tuebingen, Germany), Sancy Leachman (University of Utah, Salt Lake City, UT), Boris Bastian (University of California San Francisco, San Francisco, CA) |
| 8:35 – 9:00 am |
The genetics of melanoma: Searching for new therapeutic targets |
| 9:00 – 9:25 am |
Molecular prognostics in melanoma |
| 9:25 – 9:50 am |
Germline mutations and genetics of melanoma |
| 9:50 – 10:15 am |
Somatic mutations in melanoma |
| 10:15 – 10:40 am | Panel Discussion (Garbe, Bastian, Leachman) |
| 10:40 – 11:05 am | Break |
| 11:05 – 12:45 pm |
Oral session III: Translational and clinical studies |
| 11:05 am |
"APE/Ref-1, a druggable target for therapy of human melanoma" |
| 11:20 am |
"RhoJ and Pak kinases regulate melanoma chemoresistance by suppressing pathways that sense DNA damage" |
| 11:35 am |
"The effect of Ccl22 on regulatory T cells and depigmentation in mice" |
| 11:50 am |
"Targeting C-MYC with small molecules as a novel anti-melanoma therapy" |
| 12:05 pm |
"Sulforaphane protects melanocytes and epidermal tissue from individuals at increased risk for melanoma from the effects of UV radiation: role of thioredoxin reductase 1" |
| 12:20 pm |
"The landscape of mutations in melanomas revealed by exome sequencing" |
| 12:45 – 1:45 pm | Lunch |
| 1:45 pm – 4:00 pm |
Plenary session IV: New approaches to melanoma treatment |
| 1:45 – 2:05 pm | Adaptive T cell therapy Toni Ribas (University of California, Los Angeles, CA) |
| 2:05 – 2:25 pm |
Immunotherapy for melanoma |
| 2:25 – 2:45 pm |
Targeted therapies for melanoma |
| 2:45 – 3:05 pm |
Resistance to chemotherapy in melanoma: genetic solutions? |
| 3:05 – 3:25 pm |
New clinical trials in melanoma |
| 3:25 – 3:45 pm |
What's New in melanoma surgery? |
| 3:45 – 4:00 pm | Panel Discussion (Kirkwood, Grossmann, Garbe) |
| 4:00 pm | Adjourn |
