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Brad Cairns

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Bradley R. Cairns Ph.D.

Howard Hughes Medical Institute
Associate Professor
Department of Oncological Sciences
Huntsman Cancer Institute
University of Utah, Building 555
2000 Circle of Hope, Room 4362
Salt Lake City, Utah 84112-0555

Phone: (801)585-1822
FAX: (801) 585-6410

Email: brad.cairns@hci.utah.edu

RESEARCH AND PROFESSIONAL EXPERIENCE:

Education

June 1987 — B.S. Lewis and Clark College
Chemistry (Honors)

April 1995 — Ph.D. Stanford University, Cell Biology

Advisor; Roger Kornberg Ph.D., Professor

Positions Held

May 1995 — American Cancer Society Postdoctoral Fellow

May 1996 — Dept. of Structural Biology, Stanford University

Advisor; Roger Kornberg Ph.D., Professor

May 1996 — Leukemia Society of America Postdoctoral Fellow

June 1998 — Dept. of Genetics, Harvard Medical School

Advisor; Fred Winston Ph.D., Professor

June 1998 — Huntsman Cancer Institute, University of Utah School of Medicine

Assistant Professor, Department of Oncological Science

July 2000 — Assistant Investigator, Howard Hughes Medical Institute

Publications

Cairns, B.R., Collard, M.L. and Landfear, S.M. A developmentally-regulated gene from Leishmania encodes a putative membrane transport protein. Proc. Natl. Acad. Sci. USA 86, 7682-7686 (1989)

Stein, D.S., Cairns, B.R. and Landfear, S.M. A developmentally-regulated transporter in Leishmania is encoded by a family of clustered genes. Nulc. Acids Res. 18, 1549-1547 (1990)

Genske, J.E., Cairns, B.C., Stack, S.P. and Landfear, S.M. Structure and regulation of histone H2B mRNA’s from Leishmania entriettii. Mol. Cell.Biol. 11, 240-249 (1991)

Cairns, B.R., Ramer, S.W. and Kornberg, R.D. Order of action of components in the mating pathway revealed with a dominant allele of the STE11 kinase and the multiple phosphorylation of the STE7 kinase. Genes and Dev. 6, 1305-1318 (1992)

Cairns, B.R., Kim, Y.J., Sayre, M.H., Laurent, B.C. and Kornberg, R.D. A multisubunit complex containing the SWI1/ADR6, SWI2/SNF2, SWI3, SNF5 and SNF6 gene products isolated from yeast. Proc. Natl. Acad. Sci. USA 91, 1950-1954 (1994)

Treich, I., Cairns, B.R., Santos, T., Brewster, E. and Carlson, M. SNF11, a new component of the yeast SNF-SWI complex that interacts with a conserved region of SNF2. Mol. Cell Biol. 15, 4240-4248 (1995)

Cairns, B.R., Henry, L.H. and Kornberg, R.D. TFG3/TAF30/ANCI, a component of the yeast SWI/SNF complex that is similar to the leukemogenic proteins ENL and AF-9. Mol. Cell. Biol. 16, 3308-3316 (1996)

Bardwell, L., Cook, J.G., Chang, E.C., Cairns, B.R. and Thorner, J. Signaling in the yeast pheromone response pathway: specific and high-affinity interaction of the mitogen-activated protein (MAP) kinase Kss1 and Fus3 with the upstream MAP kinase STE7. Mol. Cell Biol. 16, 3637-3650 (1996)

Wang, W., Yutong, X., Zhou, S., Kuo, A., Cairns, B.R. and Crabtree, G.R. Diversity and specialization of mammalian SWI/SNF complexes. Genes and Dev. 10, 2117-2130 (1996)

Cairns, B.R., Levinson, R.L., Yamamoto, K.R. and Kornberg, R.D. Essential role of Swp73p in the function of yeast SWI/SNF complex. Genes and Dev. 10, 2131-2144 (1996)

Miller, M.E., Cairns, B.R., Levinson, R.L., Yamamoto, K.R., Engel, D.A. and Smith, M.M. Adenovirus E1A Blocks SWI/SNF-dependent transcriptional activation. Mol. Cell. Biol. 16, 5737-5743 (1996)

Cairns, B.R., Lorch, Y., Li, Y., Lacomis, L., Erdjument-Bromage, H., Tempst, P., Du, J., Laurent, B. and Kornberg, R.D. RSC, an abundant, essential chromatin-remodeling complex. Cell 87, 1249-1260 (1996)

Cao, Y., Cairns, B.R., Kornberg, R.D. and Laurent, B.C. Sfh 1p, a component of a novel chromatin remodeling complex, is required for cell cycle progression. Mol. Cell Biol. 17, 3323-3334 (1997)

Cairns, B.R. Chromatin remodeling machines ­ similar motors, ulterior motives. TIBS. 23, 20-25 (1998)

Lorch, Y., Cairns, B.R., Zheng, M. and Kornberg, R.D. Activated RSC-nucleosome complex. Cell 94, 29-34 (1998)

Cairns, B.R., Tempst, P., Winston, F. and Kornberg, R.D. Actin-related proteins are shared functional components of the chromatin remodeling complexes RSC and SWI/SNF. Molecular Cell 2, 639-651 (1998)

Whitehouse, I., Flaus, A., Cairns, B.R., White, M.F., Workman, J., and Owen-Hughes, T. Catalytic nucleosome mobilisation mediated by the SWI/SNF complex. Nature 400, 784-787 (1999)

Neely, K.E., Hassan, A.H., Wallberg, A.E., Steger, D.J., Cairns, B.R., Wright, A.P., and Workman, J. Activation domain-mediated targeting of the SWI/SNF complex to promoters stimulates transcription from nucleosome arrays. Molecular Cell 2, 649-655 (1999)

Cairns, B.R., Schlichter, A., Tempst, P., Kornberg, R. D., and Winston, F. Rsc1 and Rsc2 are in distinct forms of RSC and contain AT-hook, BAH, and bromodomains essential for the function of each complex. Molecular Cell 2, 715-723 (1999)

S.M. Sengupta, M. VanKanegan, J. Persinger, C. Logie, B.R. Cairns, C.L. Peterson, and B. Bartholomew The interactions of yeast SWI/SNF and RSC with the nucleosome before and after chromatin remodeling. J. Biol. Chem. 10, 1074-1082 (2001)

Angus-Hill, M.L., Schlichter, A., Roberts, D., Erdjument-Bromage, H., Tempst, P., and Cairns, B.R. (2001) A Rsc3-Rsc30 Zinc Cluster Heterodimer Reveals New Roles for the Chromatin Remodeling Complex RSC in Gene Expression and Cell Cycle Control. Molecular Cell (in press).

Szerlong H, Saha A, Cairns BR.
The nuclear actin-related proteins Arp7 and Arp9: a dimeric module that cooperates with architectural proteins for chromatin remodeling.
EMBO J. 2003 Jun 16;22(12):3175-87.

Douglas N. Roberts, Allen J. Stewart, Jason T. Huff, and Bradley R. Cairns
The RNA polymerase III transcriptome revealed by genome-wide localization and activity-occupancy relationships.
Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):14695-700

Margaret Kasten, Heather Szerlong, Hediye Erdjument-Bromage, Paul Tempst, Michel Werner, and Bradley R. Cairns
Tandem bromodomains in the chromatin remodeler RSC recognize acetylated histone H3 Lys 14.
EMBO J. 2004 (23) 1348-1359

Zhang H, Richardson DO, Roberts DN, Utley R, Erdjument-Bromage H, Tempst P, Cote J, Cairns BR
The Yaf9 component of the SWR1 and NuA4 complexes is required for proper gene expression, histone H4 acetylation, and Htz1 replacement near telomeres
Mol Cell Biol. 2004 Nov;24(21):9424-36

Schlichter, A., and Cairns, B.R. (2005) Histone trimethylation by Set1 is coordinated by the RRM, autoinhibitory and catalytic domains. EMBO Journal, 24, 1222-1231.

Chai, B., Huang, J., Cairns, B.R. and Laurent, B.C. (2004) Distinct roles for the RSC and Swi/Snf ATP-dependent chromatin remodelers in DNA double-stranded break repair. Genes Dev. 19(14):1656-61.

Saha, A., Wittmeyer, J., and Cairns, B.R. (2005) Chromatin remodeling through DNA translocation from an internal nucleosomal site. Nature Structural & Mol. Biol., 12(9):747-55.

Wilson, B., Erdjument Bromage, H., Tempst, P., and Cairns B.R. The RSC chromatin remodeling complex bears an essential yeast-specific module with broad functional roles.  Genetics (in press)

Zhang, H., Roberts, D., and Cairns, B.R. (2005) Genome-wide dynamics of Htz1, a conserved histone H2A variant that poises repressed genes for activation through histone loss. Cell

Guoping Da, Jeffrey Lenkart, Kehao Zhao, Ramin Shiekattar, Bradley R. Cairns, and Ronen Marmorstein. (2006) Structure and function of the SWIRM domain, a conserved protein module found in chromatin regulatory complexes. PNAS 103(7):2057-2062. Supplemental method and images for above Table 3 Table 4

 

Last Modified: Monday, March 20, 2006

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