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We are interested in how chromatin structure helps regulate gene transcription. We address and approach this broad issue in several ways. First, we purify and characterize large protein complexes that remodel and modify chromosome structure. We are also interested in epigenetics, and how chromatin structure and DNA methylation/demethylation dynamics are utilized in germ cells to poise the genome for development, and in embryos to guide developmental processes. We use genetic, biochemical and genomic methods to address these problems, and utilize yeast, zebrafish, and human cells.
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