Emergent Recent advances in the molecular pathogenesis of Ewing's sarcoma. 2010. 

Emergent Properties of EWS/FLI Regulation via GGAA Microsatellites in Ewing's Sarcoma. 2010. 

EWS/FLI and Its Downstream Target NR0B1 Interact Directly to Modulate Transcription and Oncogenesis in Ewing's Sarcoma. 2009. 

Small Round Cell Sarcomas. 2009. 

GSTM4 is a microsatellite-containing EWS/FLI target involved in Ewing's sarcoma oncogenesis and therapeutic resistance. 2009. 

Braun BS and Lessnick SL. Pediatric malignancies: update on sarcomas and leukemia development in children. Current Opinion in Genetics and Development 2009. 19:92-96.

Gangwal K and Lessnick SL. Microsatellites are EWS/FLI response elements: Genomic "junk" is EWS/FLI's treasure. Cell Cycle 2008 Oct 15; 7(20), 3127 - 3132 

Gangwal K, Sankar S, Hollenhorst PC, Kinsey M, Haroldsen SC, Shah AA, Boucher KM, Watkins WS, Jorde LB, Graves BJ, Lessnick SL. Microsatellites as EWS/FLI response elements in Ewing's sarcoma. Proc Natl Acad Sci U S A. 2008 Jul 22;105(29):10149-54.

• Supplemental Data

Owen LA, Kowalewski AA, and Lessnick SL. EWS/FLI mediates transcriptional repression via NKX2.2 during oncogenic transformation in Ewing's sarcoma. PLoS ONE. 2008 April; 3(4): 1965.

• Supplemental Data

Hancock JD and Lessnick SL. A transcriptional profiling meta-analysis reveals a core EWS-FLI gene expression signature. Cell Cycle 2008. January 15; 7(2):250-256.

• Supplemental Data

Braunreiter CL, Hancock JD, Coffin CM, Boucher KM, Lessnick SL. Expression of EWS-ETS fusions in NIH3T3 cells reveals significant differences to Ewing's sarcoma. Cell Cycle. 2006 Dec;5(23):2753-9

• Supplemental Data

Kinsey, M., Smith, R., and Lessnick, S.L. (2006) NR0B1 Is Required for the Oncogenic Phenotype Mediated by EWS/FLI in Ewing's Sarcoma. Mol Cancer Res 4, 851-859.

• Supplemental Data

Owen LA, Lessnick SL. Identification of target genes in their native cellular context: an analysis of EWS/FLI in Ewing's sarcoma. Cell Cycle. 2006 Sep;5(18):2049-53

Smith R, Owen LA, Trem DJ, Wong JS, Whangbo JS, Golub TR, Lessnick SL. Expression profiling of EWS/FLI identifies NKX2.2 as a critical target gene in Ewing's sarcoma. Cancer Cell. 2006 May;9(5):405-16

• Supplemental Data 

McAllister NR, Lessnick SL. The potential for molecular therapeutic targets in Ewing's sarcoma. Curr Treat Options Oncol. 2005 Nov;6(6):461-71

Randall RL, Lessnick SL, Johnson B, Joyner DE. The potential for molecular therapeutic targets in Ewing's sarcoma. Current Op in Ortho. 2004 Dec;15(6):456-467

Lessnick SL, Dacwag CS, Golub TR. The Ewing's sarcoma oncoprotein EWS/FLI induces a p53-dependent growth arrest in primary human fibroblasts. Cancer Cell. 2002 May;1(4):393-401 

• Supplemental Data

Lessnick, et al, Oncogene 10, 423-31, 1995

Lessnick, et al., Science 250, 836-838, 1990, technical comments.