At the Ullman Lab, we are investigating how morphological rearrangements in cell form are coordinated during cell division. We are also studying a protein partnership that we discovered confers aggressive tumor growth. Ultimately, we would like to use information from our projects to gain insight into tumorigenesis as well as to discover targets for new chemotherapy strategies.
What began as a goal to understand the roles of the nuclear pore protein Nup153 at both interphase and mitosis has led us to an interest in how dispersal and reformation of the nuclear envelope is coordinated with other cell cycle events. We also study the protein partners PDCD4 and PRMT5. We have shown that these two proteins are useful when combined as a biomarker signature and now aim to unlock the mechanistic pathway underlying their collaboration in tumor growth. These projects are focused on fundamental aspects of cell biology with the overarching goal of revealing how cell function is deregulated in cancer and identifying new strategies to block cancerous cell growth.