Yuxia Zhang (2010- )
Mentor: Wang
Li H, Chen F, Yu L, Liu M, Chen H, Zhang Y, Liu X. 2002. Expression of inflammation related enzymes during experimental rat lung carcinogenesis. Zhonghua Zhong Liu Za Zhi. Jul;24(4):316-9. PubMed PMID: 12408753.
Chen H, Diao L, Chen F, Liu X, Zhang Y, Ye B, Liu M. 2002. The relationship between caspase-3 expression and cell proliferation in rat lung squamous cell carcinoma. Zhongguo Fei Ai Za Zhi. Dec 20;5(6):440-443. Chinese. PubMed PMID: 21333226.
Chen F, Chen H, Tao H, Zhang Y, Ye B, Liu M. 2004. Different expressions of p53 gene family members and their clinical significance in human non-small cell lung cancer. Zhongguo Fei Ai Za Zhi. Aug 20;7(4):339-343. Chinese. PubMed PMID:21241556.
Zhang Y, Yu S, Ou-Yang J, Xia D, Wang M, Li J. 2005. Effect of protein kinase C alpha, caspase-3 and survivin on apoptosis of oral cancer cells induced by staurosporine. Acta Pharmacol Sin. Nov;26(11):1365-72. PMID: 16225760.
Zhang Y, Lai B, Chen H, Yue W, Yang F, Xia D, Xiao J, Ye B, Liu M. 2006. Induction of pulmonary precancerous lesions by tobacco-specific NNK in Wistar rats. Zhongguo Fei Ai Za Zhi. Apr 20;9(2):152-156. Chinese. PubMed PMID: 21144301.
Cheng H, Xia B, Guo Q, Zhang L, Wang F, Jiang L, Wang Z, Zhang Y, Li C. 2007. Sinomenine attenuates 2, 4, 6-trinitrobenzene sulfonic acid-induced colitis in mice. Int Immunopharmacol. May;7(5):604-11. PubMed PMID: 17386408.
Ye B, Zhang Y, Yang F, Chen HL, Xia D, Liu MQ, Lai BT. 2007. Induction of lung lesions in Wistar rats by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and its inhibition by aspirin and phenethyl Isothiocyanate. BMC Cancer. May 29;7:90. PMID: 17535415
He N, Park K, Zhang Y, Huang J, Lu S, Wang L.2008. Epigenetic inhibition of nuclear receptor small heterodimer partner is associated with and regulates hepatocellular carcinoma growth. Gastroenterology. Mar;134(3):793-802. PubMed PMID: 18325392.
Zhang Y, Chen HL, Ye B, Yang F, Yu LY. 2008. Study on expression and methylation of caveolin 1 gene in non-small cell lung cancer. Zhonghua Bing Li Xue Za Zhi. May;37(5):300-4. Chinese. PMID:18956646
Zhang Y, Xu P, Park K, Choi Y, Moore DD, Wang L. 2008. Orphan receptor small heterodimer partner suppresses tumorigenesis by modulating cyclin D1 expression and cellular proliferation. Hepatology. Jul;48(1):289-98. PubMed PMID:18537191.
Song G, Zhang Y, Wang L. 2009. MicroRNA-206 targets notch3, activates apoptosis, and inhibits tumor cell migration and focus formation. J Biol Chem. Nov 13;284(46):31921-7. PubMed PMID: 19723635; PubMed Central PMCID: PMC2797263.
Li M, Ye B, Zhang Y, Chen H, Xia D, Liu M, Yang F. 2009. Proteomic analysis of serum in lung cancer induced by 3-methylcholanthrene. J Biomed Biotechnol. 2009; 397910. PubMed PMID: 19794824; PubMed Central PMCID: PMC2753780.
Chen H, Xue J, Zhang Y, Zhu X, Gao J, Yu B. 2009. Comparison of quantum dots immunofluorescence histochemistry and conventional immunohistochemistry for the detection of caveolin-1 and PCNA in the lung cancer tissue microarray. J Mol Histol. Aug;40(4):261-8. PubMed PMID: 19908148.
Zhang Y, Soto J, Park K, Viswanath G, Kuwada S, Abel ED, Wang L. 2010. Nuclear receptor SHP, a death receptor that targets mitochondria, induces apoptosis and inhibits tumor growth. Mol Cell Biol. Mar;30(6):1341-56. PubMed PMID: 20065042; PubMed Central PMCID: PMC2832505.
Zhou T, Zhang Y, Macchiarulo A, Yang Z, Cellanetti M, Coto E, Xu P, Pellicciari R, Wang L. 2010. Novel polymorphisms of nuclear receptor SHP associated with functional and structural changes. J Biol Chem. Aug 6;285(32):24871-81. PubMed PMID: 20516075; PubMed Central PMCID: PMC2915723.
Pan X, Zhang Y, Wang L, Hussain MM. 2010. Diurnal regulation of MTP and plasma triglyceride by CLOCK is mediated by SHP. Cell Metab. Aug 4;12(2):174-86. PubMed PMID: 20674862; PubMed Central PMCID: PMC2925198.
Weaver BP*, Zhang Y*, Hiscox S, Guo GL, Apte U, Taylor KM, Sheline CT, Wang L, Andrews GK.2010. Zip4 (Slc39a4) expression is activated in hepatocellular carcinomas and functions to repress apoptosis, enhance cell cycle and increase migration. PLoS One. Oct 4;5(10). pii: e13158. PubMed PMID: 20957146; PubMed Central PMCID: PMC2950147. (*co-first author)
Li M, Chen H, Diao L, Zhang Y, Xia C, Yang F.2010. Caveolin-1 and VEGF-C promote lymph node metastasis in the absence of intratumoral lymphangiogenesis in non-small cell lung cancer. Tumori. Sep-Oct;96(5):734-43. PubMed PMID: 21302621.
Zhang Y, Hagedorn CH, Wang L. 2011. Role of nuclear receptor SHP in metabolism and cancer. Biochim Biophys Acta. Aug;1812(8):893-908. Invited Review. PubMed PMID: 20970497; PubMed Central PMCID: PMC3043166.
Zhang Y, Wang L.2011. Nuclear receptor SHP inhibition of Dnmt1 expression via ERR?. FEBS Lett. May 6;585(9):1269-75. PubMed PMID: 21459093; PubMed Central PMCID: PMC3134389.
Zhang Y, Bonzo JA, Gonzalez FJ, Wang L. 2011. Diurnal regulation of the early growth response 1 (Egr-1) protein expression by hepatocyte nuclear factor 4alpha (HNF4alpha) and small heterodimer partner (SHP) cross-talk in liver fibrosis. J Biol Chem. Aug 26;286(34):29635-43. PubMed PMID: 21725089; PubMed Central PMCID: PMC3191004.
Zhang Y, Yang Z, Whitby R, Wang L. 2011. Regulation of miR-200c by nuclear receptors PPAR?, LRH-1 and SHP. Biochem Biophys Res Commun. Nov 11. [Epub ahead of print] PubMed PMID: 22100809.
Tracy Denison (2010- )
Mentor: Bae
Denison TA, Koch CF, Shapiro IM, Schwartz Z, Boyan BD. Inorganic Phosphate Modulates Responsiveness to 24,25(OH)2D3 in Chondrogenic ATDC5. J Cell Biochem. 2009 May 1;107(1):155-62.
Boyan BD, Hurst-Kennedy J, Denison TA, Schwartz Z. 24R,25-Dihydroxyvitamin D3 [24R,25(OH)(2)D(3)] controls growth plate development by inhibiting apoptosis in the reserve zone and stimulating response to 1alpha,25(OH)(2)D(3) in hypertrophic cells. J Steroid Biochem Mol Biol. 2010 Mar 20.
Schwartz Z, Denison TA, Bannister SR, Cochran DL, Liu YH, Lohmann CH, Wieland M, Boyan BD. Osteoblast Response to Fluid Induced Shear Depends on Substrate Microarchitecture and Varies with Time. J Biomed Mater Res A. 2007 Oct;83(1):20-32.
Denison TA, Doroudi M, Skourtis TK, Schwartz Z, Boyan BD. Fluid Shear Stress Inhibits Differentiation of Growth Plate Resting Zone Chondrocytes and Chondrogenic ATDC5 Cells, Partially Via Integrin Beta 1. (In final draft awaiting approval of all authors prior to submission).
Stephen Piccolo (2010- )
Mentor:Bild
Piccolo SR, Camp N, Frey LJ, 2008, "Polygenic model for predicting breast cancer risk via genome-wide polymorphisms," AMIA Annu Symp Proc. Nov 6:1094.
*Piccolo SR, Frey LJ, 2008, "Somatic mutation signatures of cancer," AMIA Annu Symp Proc. Nov 6:202-6. PMCID:PMC2655983.
*Piccolo SR, Abo RP, Allen-Brady K, Camp NJ, Knight S, Anderson JL, Horne BD, 2009, "Evaluation of genetic risk scores for lipid levels using genome-wide markers in the Framingham Heart Study," BMC Proc. Dec 15;3 Suppl 7:S46. PMCID:PMC2795945.
*Crockett DK, Piccolo SR, Ridge PG, Margraf RL, Lyon E, Williams MS, Mitchell JA, 2011, "Predicting phenotypic severity of uncertain gene variants in the RET proto-oncogene," PLoS One. Mar 30;6(3):e18380. PMCID:PMC3068179.
*Frey LJ, Piccolo SR, Edgerton ME, 2011, "Multiplicity: an organizing principle for cancers and somatic mutations," BMC Med Genomics. 2011 Jun 29;4(1):52. PMCID:PMC3150236.
Marc Elgort (2011- )
Mentor: Frost
Coghlan MJ, Jacobson PB, Lane B, Nakane M, Lin CW, Elmore SW, Kym PR, Luly JR, Carter GW, Turner R, Tyree CM, Hu J, Elgort M, Rosen J, Miner JN, 2003, "A novel anti-inflammatory maintains glucocorticoid efficacy with reduced side effects," Mol Endocrinol. May;17(5):860-9.
Elgort MG, Herrmann MG, Erali M, Durtschi JD, Voelkerding KV, Smith RE, 2004, "Extraction and amplification of genomic DNA from human blood on nanoporous aluminum oxide membranes," Clin Chem. Oct;50(10):1817-9.
*Dames S, Bromley LK, Herrmann M, Elgort M, Erali M, Smith R, Voelkerding KV, 2006, "A single-tube nucleic acid extraction, amplification, and detection method using aluminum oxide," J Mol Diagn. Feb;8(1):16-21. PMCID:PMC2867575.
*Modzelewska K, Elgort MG, Huang J, Jongeward G, Lauritzen A, Yoon CH, Sternberg PW, Moghal N, 2007, "An activating mutation in sos-1 identifies its Dbl domain as a critical inhibitor of the epidermal growth factor receptor pathway during Caenorhabditis elegans vulval development," Mol Cell Biol. May;27(10):3695-707. PMCID:PMC0899997.
*Kaadige MR, Elgort MG, Ayer DE, 2010, "Coordination of glucose and glutamine utilization by an expanded Myc network," Transcription. 2010 Jul;1(1):36-40. PMCID:PMC3035186.
*Elgort MG, O'Shea JM, Jiang Y, Ayer DE, 2010, "Transcriptional and Translational Downregulation of Thioredoxin Interacting Protein Is Required for Metabolic Reprogramming during G(1)," Genes Cancer. Sep;1(9):893-907. PMCID:PMC3092257.
Amy Hawkins (2011- )
Mentor: Rutter
*Hawkins AJ, Subler MA, Akopiants K, Wiley JL, Taylor SM, Rice AC, Windle JJ, Valerie K, Povirk LF, 2009, "In vitro complementation of Tdp1 deficiency indicates a stabilized enzyme-DNA adduct from tyrosyl but not glycolate lesions as a consequence of the SCAN1 mutation," DNA Repair (Amst). May 1;8(5):654-63. PMCID:PMC2844109.
*Golding SE, Morgan RN, Adams BR, Hawkins AJ, Povirk LF, Valerie K, 2009, "Pro-survival AKT and ERK signaling from EGFR and mutant EGFRvIII enhances DNA double-strand break repair in human glioma cells," Cancer Biol Ther. Apr;8(8):730-8. PMCID:PMC2863288.
*Shultz JC, Goehe RW, Wijesinghe DS, Murudkar C, Hawkins AJ, Shay JW, Minna JD, Chalfant CE, 2010, "Alternative splicing of caspase 9 is modulated by the phosphoinositide 3-kinase/Akt pathway via phosphorylation of SRp30a," Cancer Res. Nov 15;70(22):9185-96. PMCID:PMC3059118.
*Shultz JC, Goehe RW, Murudkar CS, Wijesinghe DS, Mayton EK, Massiello A, Hawkins AJ, Mukerjee P, Pinkerman RL, Park MA, Chalfant CE, 2011, "SRSF1 Regulates the Alternative Splicing of Caspase 9 Via A Novel Intronic Splicing Enhancer Affecting the Chemotherapeutic Sensitivity of Non-Small Cell Lung Cancer Cells," Mol Cancer Res. Jul;9(7):889-900. PMCID:PMC3140550.
Hawkins AJ, Golding SE, Khalil A, Valerie K, 2011, "DNA double-strand break - induced pro-survival signaling," Radiother Oncol. 2011 Jul 2.
Marc Jean-Paul De La O
*De La O JP, Emerson LL, Goodman JL, Froebe SC, Illum BE, Curtis AB, Murtaugh LC, 2008, "Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia," Proc Natl Acad Sci U S A. Dec 2;105(48):18907-12. PMCID:PMC2585942.
*De La O JP, Murtaugh LC, 2009, "Notch and Kras in pancreatic cancer: at the crossroads of mutation, differentiation and signaling," Cell Cycle. Jun 15;8(12):1860-4. PMCID:PMC2719432.
* Denotes co-first authorship.
**These authors contributed equally.
