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Nuclear Control of Cell Growth and Differentiation

NC Membership Directory


ccsgnuclearprogramResearch in the Nuclear Control of Cell Growth and Differentiation (NC) program focuses on fundamental processes in the cell nucleus that regulate the cell's biological function and go awry in the cancer cell. Researchers in the NC program study a variety of basic processes, including DNA replication, recombination, and repair; genetics and epigenetics; transcriptional regulation, RNA metabolism, and the role of these processes in cell growth; and division, metabolism, and oncogenic transformation. Program members use multiple model systems such as yeast, C. elegans, Drosophila, zebrafish, mouse, and patient-derived cell lines.

The NC program facilitates individual and cooperative research projects of representatives from many academic units on campus. It provides forums to encourage the translation of these basic research projects to more cancer-focused investigations through coordination with disease-based programs of the Cancer Center Support Grant.

The Nuclear Control of Cell Growth and Differentiation Program currently receives approximately $10.1 million per year of direct research support from the National Institutes of Health, the American Cancer Society, the National Science Foundation, and other funding agencies, with 13% coming from the National Cancer Institute. Cancer-focused articles published between 2003-2009 total 220, of which 14% are inter-programmatic and 9% are intra-programmatic publications.

 

Bradley Cairns, PhD
Leader
cairns bio

 

 

 

 

 

 

 

HCI, Room 4362
(801) 585-1822
(801) 581-3952 FAX

 

 

 

NC Membership Directory



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  • Ayer, Donald

    Department: Oncological Sciences
    E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
    Phone: (801) 581-5597
    Research Interest: Transcription regulation, nuclear oncogenes

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  • Bass, Brenda

    Department: Biochemistry
    E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
    Phone: (801) 581-4884
    Research Interest: Double-stranded RNA (dsRNA), RNA editing by adenosine deaminases that act on RNA (ADARs), and RNA interference (RNAi)

  • Bhaskara, Srividya

    Department: Radiation Oncolgy
    E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
    Phone: (801) 213-4219
    Research Interest: Functions of histone deacetylases (HDACs) in genomic stability maintenance and inhibition

  • Burrows, Cynthia

    Department: Chemistry
    E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
    Phone: (801) 585-7290
    Research Interest: Chemistry and biochemistry of DNA damage

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  • Cairns, Bradley

    Department: Oncological Sciences
    E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
    Phone: (801) 585-1822
    Research Interest: Chromatin remodeling, transcription

  • Capecchi, Mario

    Department: Human Genetics
    E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
    Phone: (801) 581-7096
    Research Interest: Mammalian development genetic recombination

  • Carroll, Dana

    Department: Biochemistry
    E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
    Phone: (801) 581-5977
    Research Interest: Gene targeting

  • Chandrasekharan, Mahesh

    Department: Radiation Oncology
    E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
    Phone: (801) 213-4220
    Research Interest: Regulation and function of histone modifications in gene transcription and genome stability maintenance pathways

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  • Engel, Michael

    Department: Pediatrics; Division of Pediatric Hematology/Oncology
    E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
    Phone: (801) 587-3882
    Research Interest: Molecular pathogenesis of acute leukemias and the perturbations of regulatory relationships that govern normal hematopoeisis

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  • Formosa, Timothy

    Department: Biochemistry
    E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
    Phone: (801) 581-5435
    Research Interest: DNA replication in yeast

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  • Golic, Kent

    Department: Biology
    E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
    Phone: (801) 581-8726
    Research Interest: Drosophila genetics; chromosome structure and function

  • Graves, Barbara

    Department: Oncological Sciences
    E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
    Phone: (801) 581-7308
    Research Interest: DNA-protein interactions, eukaryotic transcriptional regulation

  • Grunwald, David

    Department: Human Genetics
    E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
    Phone: (801) 581-6421 
    Research Interest: Cell differentiation in the zebrafish

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  • Hagedorn, Curt

    Department: Medicine; Division of Gastroenterology
    E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
    Phone: (801) 587-4618
    Research Interest: RNA binding protein eIF-4E and how increases in 4E drive tumor progression of epithelial cancers

  • Hill, Christopher

    Department: Biochemistry
    E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
    Phone: (801) 585-5536
    Research Interest: The structure and mechanisms of proteins that function in proteasome activation, the HIV life cycle, and nucleosome remodeling and reorganization

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  • Huang, Eric

Department: Neurosurgery
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Phone: (801) 585-3221
Research Interest: Tumor hypoxia and molecular mechanisms underlying tumorigenesis and progression

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  • Jensen, Randy

    Department: Neurosurgery
    E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
    Phone: (801) 581-6908
    Research Interest: Brain tumor angiogenesis and hypxoxia

  • Jones, David

    Department: Oncological Sciences
    E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
    Phone: (801) 585-6107
    Research Interest: Colon cancer, retinoic acid, DNA methylation, cancer therapeutics

  • Jones, Kevin B.

    Department: Orthopaedics
    E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
    Phone: (801) 587-4682
    Research Interest: Mesenchymal transformation and sarcoma progression

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  • Leibold, Elizabeth

    Department: Medicine; Division of Hematology
    E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
    Phone: (801) 585-5002
    Research Interest: Gene regulation by stress

  • Lessnick, Stephen

    Department: Pediatrics; Division of Pediatric Hematology/Oncology
    E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
    Phone: (801) 585-9268
    Research Interest: Ewing's sarcoma pathogenesis

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  • Miles, Rodney

    Department: Pathology
    E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
    Phone: (801) 213-3488
    Research Interest: The role of gene copy number changes in the biology and prognosis of pediatric lymphoblastic leukemia and Burkitt lymphoma

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  • Nix, David

    Department: Oncological Sciences
    E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
    Phone: (801) 587-4611
    Research Interest: Use of microarray and next generation sequencing technologies to address fundamental questions about molecular biology and genomics

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  • Rutter, Jared

    Department: Biochemistry
    E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
    Phone: (801) 581-3340
    Research Interest: Metabolic signaling in cancer

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  • Schiffman, Joshua

    Department: Oncological Sciences
    E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
    Phone: (801) 587-4745
    Research Interest: Pediatric hereditary cancer syndromes, CNVs, and leukemia

  • Stewart, Rodney

    Department: Oncological Sciences
    E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
    Phone: (801) 466-3533
    Research Interest: Xenotropic murine-like retrovirus and its role in prostate cancer

  • Swaminathan, Sankar

    Department: Medicine; Division of Infectious Diseases
    E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
    Phone: (801) 581-8812
    Research Interest: Post-transcriptional gene regulation in herpes viruses and RNA export

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  • Tantin, Dean

    Department: Pathology
    E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
    Phone: (801) 587-3035
    Research Interest: Mammalian gene regulation in cancer

  • Tavtigian, Sean

    Department: Oncological Sciences
    E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
    Phone: (801) 587-4258
    Research Interest: Identification and characterization of intermediate risk breast cancer susceptibility genes and analysis of unclassified variants observed during clinical testing of high-risk cancer susceptibility genes

  • Thummel, Carl

    Department: Human Genetics
    E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
    Phone: (801) 581-2937
    Research Interest: Gene expression, steroid hormone action

 

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